Structure-activity relationship (SAR) by NMR is a technique developed in 1996 by Stephen Fesik at Abbot Laboratories. SAR by NMR is the first experimental demonstration of the fragment-based approach to drug discovery. The method uses NMR spectroscopy to probe the surface area surrounding a protein’s active site for ligand binders. A small, structurally diverse chemical library is screened by NMR with the goal of identifying ligands that bind proximal to each other in the protein’s active site.
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